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Expression of ABC transporters in cell cultures of non-small cell lung cancer: effect of selected targeted drugs
Žofajová, Barbora ; Hofman, Jakub (advisor) ; Červený, Lukáš (referee)
Charles University Faculty of Pharmacy in Hradec Králové Department of Pharmacology & Toxicology Student: Barbora Žofajová Supervisor: doc. RNDr. Jakub Hofman, Ph.D. Title of diploma thesis: Expression of ABC transporters in non-small cell lung carcinoma cell cultures: effect of selected targeted drugs ABC transporters form a special family of transmembrane proteins, their function is the active efflux of substrates into the extracellular environment. These transporters are expressed in normal tissues and tumor cells. Thus, they influence drug pharmacokinetics and play a role in the development of multidrug resistance (MDR). Tyrosine kinases have essential functions ranging from proliferation to differentiation and cell death, their mutation can cause carcinogenesis. Finding, exploring, and inhibiting the functions of these targets is a promising strategy to treat cancer. This work aimed to determine whether the selected drugs are involved in pharmacokinetic interactions that are based on inductions of ABC efflux transporter genes and whether they have the potential to affect MDR phenotype of tumor cells. The drugs, which we studied, were three targeted anticancer drugs (capmatinib, pralsetinib, and tazemetostat) and two well- known chemotherapeutic drugs (pemetrexed and methotrexate). First, we...
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Radiotherapy of lung cancer in the Karlovy Vary Region
NEJEDLÁ, Klára
The study is aimed to radiotherapy of lung cancer in patients permanently living in the Karlovy Vary region. The number of newly diagnosed pulmonary cancer in the Czech Republic is nearly six and half thousand case a year. This number testifies a slight reduction in the long-term incidence of the disease. The most risky factor in the development of lung cancer is definitely smoking. The objective of the work was avaluated a set of patients from the "KKN" hospital in Cheb who are treated for lung cancer over the period from 2009 to 2013 and to highlight the importance of the representation of regional oncological centers in the treatment of lung cancer. Data about 382 patients who were treatment initiaton between 2009-2013 in the Cheb's regional cancer center, were assembled from the hospital information systém (NIS) in hospital in Cheb. Data collection was of age, where do they live, WHO staging, way of treatment, work information and year of death. Another objective of the work was to verify on the supposition that there is a higher incidence of lung cancinoma in the Karlovy Vary region where there is elevated radon index of the geological subsoil. It was found out that the ratio of patients with this disease is virtually identical in Cheb region and Karlovy Vary region. Over the period from 2009 to 2013 there were treated 617 patients for lung cancer in the Chebs's regional cancer center of whitch 382 were treated with radiotherapy. In my opinion that the closure of the radiotherapy department in the past would seriosly complicate the treatment of oncological patients from all over the region, especially a large number of patients who need of palliative treatment.
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